Cervical lymph node collision tumor consisting of metastatic squamous cell carcinoma and B-cell lymphoma.

EDUCATIONAL OBJECTIVE At the conclusion of this presentation, the participants should be familiar with the clinical and pathologic features of collision tumors in the head and neck. OBJECTIVES Present a case of collision tumor of the head and neck consisting of metastatic squamous cell carcinoma and B-cell lymphoma. Review the literature on collision tumors of the head and neck. STUDY DESIGN Case report. METHODS Retrospective case review including a review of the relevant literature. RESULTS The case of a 73 year-old-man with collision tumor of the cervical lymph nodes is presented. He had a history of resection of a squamous cell carcinoma of the nasal ala seven years prior to presentation with a neck mass. Fine needle aspiration of the mass was consistent with squamous cell carcinoma and he underwent neck dissection. Pathology revealed both squamous cell carcinoma and low grade B cell lymphoma in the same cervical lymph nodes. The patient underwent post-operative concurrent chemotherapy and radiotherapy directed at the squamous cell carcinoma. Subsequently, he initiated chemotherapy directed at the lymphoma. CONCLUSIONS Collision tumors are rare entities that consist of two neoplasms of distinct origin found in a single anatomic location. In the head and neck, collision tumors often involve an incidental well-differentiated thyroid malignancy. Collision tumor involving metastatic squamous cell carcinoma and lymphoma is an exceedingly rare finding. A multidisciplinary team approach is required to optimize and coordinate management of these synchronous malignancies.